Excerpts from "Toxicological Profile for Fluorides, Hydrogen
Fluoride, and Fluorine(F)"
by the U.S. Dept. of Health, Agency for Toxic Substances and
Disease Registry, Division of Toxicology, December 16, 1991.
"Humans administered magnesium along with fluoride as therapy
for osteoporosis had diminished joint pain and resorbed
periarticular calcium phosphate deposits (Kuhr et al. 1987)
Magnesium appeared to reduce the adverse effects of fluoride when
it was used as a treatment for osteoporosis.
"Existing data indicate that subsets of the population may be
unusually susceptible to the toxic effects of fluoride and its
compounds. These populations include the elderly, people with
magnesium deficiency, and people with cardiovascular and kidney
problems.
"People over the age of 50 have been shown to have decreased
renal fluoride clearance (Hanhijarvi 1974). This may be because
of the decreased rate of accumulation of fluoride in bones or
decreased renal function [comment: the reason there is decreased
bone F accumulation is because bone becomes saturated with it and
cannot take anymore--it then becomes more brittle]. This
decreased clearance of fluoride may indicate that elderly people
are more susceptible to fluoride toxicity. Inadequate dietary
levels of magnesium may affect the toxic effects of fluoride. In
this study, fluoride administered to magnesium-deficient dogs
prevented soft-tissue calcification but not muscle weakness and
convulsions. In rats, fluoride aggravated the hypomagnesemia
condition, which produced convulsive seizures. The symptoms of
magnesium deficiency are similar to those produced by fluoride
toxicity. This may be because of a fluoride-induced increase in
the uptake of magnesium from plasma into bone (Chiemchaisri and
Philips 1963).
"Some people with cardiovascular problems may be at increased
risk of fluoride toxicity. Fluoride inhibits glycolysis by
inhibiting enolase. However, it also inhibits energy metabolism
through the tricarboxylic acid cycle by blocking the entry of
pyruvate and fatty acids and by inhibiting succinic
dehydrogenase. Because fluoride is excreted through the kidney,
people with renal insufficiency would have impaired renal
clearance of fluoride (Juncos and Donadio 1972). People with
diabetes mellitus and heart insufficiency have also been found to
have impaired renal clearance of fluoride (Hanhijarvi 1974)."
NOTE:
Pete Wilson, Governor of California, signed a bill Monday that
requires all public water systems with at least 10,000 customers
to fluoridate.
This page was first uploaded to The Magnesium Web Site on
October 9, 1995
http://www.mgwater.com/
Healthy Water
Association--USA