MgSO4 Less Effective
Following are abstracts of several early publications on
toxicity of MgSO4, furnished to me by Dr. Seelig:
Selye H (book): The Chemical Prevention of Cardiac Necrosis.
Ronald Press, New York, 1958.
AB: ESCN (electrolyte-steroid-cardiac-necrosis) rat model;
production with Na salts listed (p.20-21, including Na2SO4); not
produced by MgSO4; prevented by MgCl2 & KCl (table 4, p. 33);
MgSO4 less effective (table 5, p.35); comparison of inhibition of
ESCN by MgCl2 (no necrosis). MgSO4, exerted no significant
inhibition of necrosis: 90% necrosis (Table 6, p. 37)
Harris AS, Estandia A, Smith H, Olsen RW, Ford TJ Jr,
Tillotson RF: Magnesium sulfate and chloride in suppression of
ectopic ventricular tachycardia accompanying acute myocardial
infarction. Am J Physiol 172:251-258, 1953.
AB: AMI from ligation of anterior descending coronary in
36 dogs: rate of ectopic ventricular tachycardia greatest 1st day
& most resistant to drugs. MgCl2 successful in 9 of 13 dogs
(70%); MgSO4 in 5 of 11 (47%).
Classen H-G, Marquardt P, Ebel H, Schumacher LA, Spath M,
Helbig J: Experimental studies on the intestinal absorption of
magnesium and its protective effects against cardiac hypertrophy
and nonocclusive necroses. In (M. Cantin, M.S. Seelig, eds)
Magnesium in Health & Disease Spectrum Publ, NY, 1980 - (2nd
Intl Sympos on Mg Quebec, 1976) pp 521-535.
AB: Only MgCl2 & MgAspHCl (MAH) protect against
(epinephrine [Ep]-induced) cardiac necrosis because they correct
pathogenic extracellular (e.c.) hypochloremic alkalosis.
Hyperglycemia after Ep was decr by each Mg salt. MgSO4 was
poorest absorbed. In (MgDef & ClDef + Ep), hyperCa &
hypoMg predominate. Both Cl-salts may be better for therapeutic
use; MgCl2 is more toxic than MAH. Summary: Rat comparative
studies of MgSO4, MgCl2, MgAsp, & MAH, for differential
absorption of Mg & uptake by blood & tissue as well as
cardioprotective in 2 disease models. On oral administration
plasma & bone Mg were significantly higher after each Cl-
containing salt than after MgSO4 or MgAsp. Except for MgSO4 in
the 2nd model, all prevented cardiac hypertrophy.
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